What to Do During a Hypoglycemia Emergency (Severe Low Blood Sugar)

02 Sep 2025

What to Do During a Hypoglycemia Emergency (Severe Low Blood Sugar) Hypoglycemia, or low blood sugar, is a common complication for individuals with di...

What to Do During a Hypoglycemia Emergency (Severe Low Blood Sugar)

Hypoglycemia, or low blood sugar, is a common complication for individuals with diabetes, particularly those taking insulin or certain oral medications. While mild to moderate episodes can usually be managed with quick-acting carbohydrates, a severe hypoglycemic event is a medical emergency requiring immediate intervention. Understanding what to do during such a crisis can be life-saving. This article provides a comprehensive guide on how to recognize, respond to, and prevent severe low blood sugar episodes.

Understanding Severe Hypoglycemia

Severe hypoglycemia occurs when blood glucose levels drop so low that the individual becomes confused, disoriented, or unconscious, rendering them unable to treat themselves. It's crucial to understand the risk factors and early warning signs, even though the individual may not always be aware of their declining state during an actual emergency.

Key Causes of Severe Hypoglycemia:

  • Excess Insulin: Taking too much insulin relative to food intake or physical activity.
  • Skipped Meals: Missing or delaying meals or snacks, especially after taking insulin.
  • Increased Physical Activity: Unplanned or excessive exercise without adjusting medication or carbohydrate intake.
  • Alcohol Consumption: Alcohol can interfere with the liver's ability to release glucose, leading to low blood sugar, especially when consumed without food.
  • Certain Medications: Some oral diabetes medications, such as sulfonylureas, can also cause hypoglycemia.
  • Kidney or Liver Problems: These conditions can affect how the body processes insulin and glucose.

Risk Factors for Severe Hypoglycemia:

| Risk Factor | Explanation | | :----------------------------- | :------------------------------------------------------------------------------------------------------------------------------------------ | | History of Hypoglycemia | Individuals who have experienced hypoglycemia before are more likely to experience it again. | | Tight Glucose Control | While aiming for tight glycemic control is important, it also increases the risk of hypoglycemia. | | Autonomic Neuropathy | This condition can mask the warning signs of hypoglycemia, making it harder to detect and treat early. | | Cognitive Impairment | Difficulty understanding or remembering diabetes management can increase the risk of medication errors and missed meals. | | Elderly Individuals | Age-related changes in metabolism and kidney function can make older adults more susceptible. |

Recognizing the Signs of Severe Hypoglycemia

Recognizing the signs of severe hypoglycemia can be challenging because the person experiencing it may be disoriented or unresponsive. Therefore, it is essential to be vigilant and know what to look for if you are caring for someone with diabetes.

Warning Signs to Watch For:

The symptoms of hypoglycemia can vary from person to person, but some common signs include:

Related reading: What Your Fasting Blood Glucose Test Is Really Telling You

  • Confusion or Difficulty Concentrating: The person may appear disoriented or unable to think clearly.
  • Slurred Speech: Their speech might be difficult to understand.
  • Irritability or Agitation: They may become unusually angry or restless.
  • Loss of Coordination: Difficulty walking or maintaining balance.
  • Seizures: In severe cases, hypoglycemia can trigger seizures.
  • Unconsciousness: The person may lose consciousness and be unresponsive.
  • Sweating: Profuse sweating even in a cool environment.
  • Pale Skin: The person's skin may appear pale or clammy.
  • Rapid Heartbeat: An increased heart rate may be noticeable.

If you observe any of these signs in someone with diabetes, it's important to act quickly.

Differential Diagnosis:

It is critical to differentiate hypoglycemia from other conditions that might mimic its symptoms, such as stroke, intoxication, or head injury. If there is any doubt, treating for hypoglycemia is generally safe and potentially life-saving.

How to Confirm Hypoglycemia:

Ideally, check the person's blood glucose level using a glucometer. A reading below 70 mg/dL (3.9 mmol/L) indicates hypoglycemia. However, if a glucometer is not immediately available, do not delay treatment based on the presence of symptoms alone.

Steps to Take During a Severe Hypoglycemia Emergency

When someone is experiencing severe hypoglycemia, immediate action is required. These steps outline what you should do:

  1. Stay Calm: It is essential to remain calm to effectively manage the situation.
  2. Assess Responsiveness:
    • If the person is conscious and able to swallow, proceed to Step 3.
    • If the person is unconscious or unable to swallow, DO NOT attempt to give them anything by mouth. Proceed to Step 4.
  3. Administer Fast-Acting Glucose (If Conscious):
    • Give them a source of fast-acting glucose, such as:
      • Glucose tablets (follow package instructions)
      • Glucose gel (apply inside the cheek)
      • Juice or regular soda (not diet)
      • Honey or syrup
    • Recheck blood glucose after 15 minutes. If it's still below 70 mg/dL (3.9 mmol/L), repeat the treatment.
  4. Administer Glucagon (If Unconscious or Unable to Swallow):
    • Glucagon is a hormone that raises blood sugar levels. It is available by prescription as an injection or nasal spray.
    • Know Where to Find Glucagon: If the person has a glucagon kit, locate it immediately. Ensure you are familiar with how to administer it. If you are unsure, follow the instructions provided with the kit.
    • Administer Glucagon Injection: Inject the glucagon into the thigh or arm muscle, as directed.
    • Administer Nasal Glucagon: Administer the nasal glucagon into one nostril as directed.
    • Call for Emergency Assistance: Immediately call emergency services (911 in the US or your local emergency number). Provide clear information about the situation, including the fact that the person is experiencing severe hypoglycemia and has been given glucagon.
  5. Position the Person Safely:
    • After administering glucagon and calling for help, place the person on their side in the recovery position to prevent choking if they vomit.
  6. Monitor and Wait for Help:
    • Stay with the person until emergency medical personnel arrive.
    • Continue to monitor their breathing and responsiveness.
    • Be prepared to provide medical history information to the responders.
  7. Inform Healthcare Providers: Following the emergency, inform the person's healthcare providers about the hypoglycemic event. They can review the person's diabetes management plan and make necessary adjustments.

Table: Comparing Glucagon Delivery Methods

Related reading: Warning Signs Your Blood Sugar Is Dangerously High Hyperglycemia

| Feature | Glucagon Injection | Nasal Glucagon | |----------------------|---------------------------------------------------|----------------------------------------------------| | Administration | Intramuscular injection (thigh or arm) | Nasal spray (one nostril) | | Ease of Use | Requires injection technique | Easier to administer, no injection needed | | Absorption | Can be affected by muscle mass/circulation | Not affected by nasal congestion | | Response Time | Generally faster | Slightly slower | | Storage | May require refrigeration | Room temperature |

Prevention of Severe Hypoglycemia

Prevention is the most effective way to manage hypoglycemia. Here are several strategies that can help prevent severe hypoglycemic events:

  1. Regular Blood Glucose Monitoring:
    • Check blood sugar levels regularly, especially before meals, before bed, and before and after exercise.
  2. Consistent Meal Timing:
    • Eat meals and snacks at consistent times each day to match insulin dosages.
  3. Carbohydrate Counting:
    • Learn how to accurately count carbohydrates in meals to adjust insulin dosages accordingly.
  4. Insulin Dosage Adjustment:
    • Work with a healthcare provider to adjust insulin dosages based on blood glucose levels, meals, and physical activity.
  5. Exercise Planning:
    • Adjust insulin dosages or consume extra carbohydrates before, during, or after exercise.
  6. Alcohol Awareness:
    • Consume alcohol in moderation and always with food. Monitor blood glucose levels closely when drinking alcohol.
  7. Medication Review:
    • Regularly review medications with a healthcare provider to identify and address potential causes of hypoglycemia.
  8. Hypoglycemia Awareness Training:
    • Participate in diabetes education programs to learn about hypoglycemia and how to prevent and treat it.
  9. Continuous Glucose Monitoring (CGM):
    • Consider using a CGM system to track glucose levels in real time and receive alerts for low blood sugar.

Hypoglycemia Action Plan:

Developing a hypoglycemia action plan with your healthcare provider is a critical step in managing diabetes and preventing emergencies. This plan should include:

  • Individualized target blood glucose ranges
  • Specific actions to take for mild, moderate, and severe hypoglycemia
  • Instructions for using glucagon
  • Contact information for healthcare providers and emergency services
  • List of medications
  • Emergency contact information

Educate Family and Friends:

Educate family members, friends, and coworkers about the signs of hypoglycemia and how to assist in an emergency. Make sure they know where glucagon is stored and how to administer it.

Conclusion

Related reading: The Fasting Blood Glucose Test How To Prepare And Interpret Your Results

Severe hypoglycemia is a serious medical emergency that requires prompt recognition and intervention. By understanding the causes, signs, and steps to take during a hypoglycemic event, you can help protect yourself or a loved one with diabetes. Prevention is key, and working closely with a healthcare team, adhering to a diabetes management plan, and educating those around you are essential steps in minimizing the risk of severe hypoglycemia. Always have a glucagon kit readily available and ensure that those close to you know how to use it. When in doubt, seek immediate medical assistance.