Severe Hypoglycemia: Warning Signs and What to Do in an Emergency

30 Aug 2025

Severe Hypoglycemia: Warning Signs and What to Do in an Emergency Severe hypoglycemia, or dangerously low blood sugar, is a serious condition primaril...

Severe Hypoglycemia: Warning Signs and What to Do in an Emergency

Severe hypoglycemia, or dangerously low blood sugar, is a serious condition primarily affecting individuals with diabetes, particularly those using insulin or certain oral medications. Recognizing the warning signs and knowing how to respond promptly can be life-saving. This article will cover what severe hypoglycemia is, its symptoms, causes, and, most importantly, the steps to take in an emergency situation.

Hypoglycemia occurs when the level of glucose (sugar) in the blood drops too low to adequately fuel the body's cells, especially the brain. Mild to moderate hypoglycemia can often be managed with quick-acting carbohydrates, but severe cases require immediate assistance. Understanding this difference is crucial for everyone, especially family members and friends of people with diabetes.

Recognizing the Warning Signs of Severe Hypoglycemia

The symptoms of hypoglycemia can vary from person to person, but generally progress as blood sugar levels continue to drop. Recognizing these early signs is paramount to preventing a severe episode.

Early Symptoms:

  • Shakiness
  • Sweating
  • Dizziness
  • Hunger
  • Irritability or anxiety
  • Rapid heartbeat
  • Blurred vision
  • Headache

As Hypoglycemia Worsens (Leading to Severe Hypoglycemia):

  • Confusion
  • Difficulty concentrating
  • Slurred speech
  • Weakness
  • Loss of coordination
  • Seizures
  • Loss of consciousness

It’s essential to note that some people may experience hypoglycemia unawareness, meaning they do not feel the early warning signs. This can be particularly dangerous and requires close management with a healthcare provider. Regularly monitoring blood glucose levels and adjusting medication dosages may be necessary to prevent severe episodes in these individuals.

Here’s a table summarizing the progression of symptoms:

| Blood Sugar Level (mg/dL) | Symptoms | | :------------------------ | :------------------------------------------------------------------------ | | 70-55 | Shakiness, sweating, dizziness, hunger, irritability | | 54-40 | Confusion, difficulty concentrating, slurred speech, weakness | | Below 40 | Seizures, loss of consciousness, potential for irreversible brain damage |

Causes of Severe Hypoglycemia

Several factors can contribute to severe hypoglycemia in people with diabetes. Understanding these causes can help individuals and their caregivers take proactive steps to prevent these episodes.

  • Excessive Insulin Dose: Taking too much insulin, or an incorrect type of insulin, is a primary cause.
  • Skipping or Delaying Meals: Failing to eat meals or snacks on time, especially after taking insulin, can lead to a drop in blood sugar.
  • Increased Physical Activity: Unplanned or excessive exercise without adjusting medication or increasing carbohydrate intake can deplete glucose stores.
  • Alcohol Consumption: Alcohol can interfere with the liver's ability to release glucose into the bloodstream, especially when consumed on an empty stomach.
  • Kidney or Liver Disease: Impaired kidney or liver function can affect insulin metabolism and glucose regulation.
  • Certain Medications: In addition to diabetes medications, certain drugs can interact with insulin or affect blood sugar levels.

Factors Increasing Risk of Severe Hypoglycemia:

  • Long-standing diabetes
  • History of frequent hypoglycemic episodes
  • Hypoglycemia unawareness
  • Cognitive impairment or other medical conditions that interfere with self-care

Understanding these causes allows for targeted preventive measures, such as careful medication management, consistent meal schedules, and proactive blood glucose monitoring.

What to Do in an Emergency: Steps to Take

When someone experiences severe hypoglycemia and is unable to treat themselves, quick and appropriate intervention is crucial. The goal is to raise their blood sugar level rapidly and prevent further complications.

Step-by-Step Guide:

  1. Check for Responsiveness: Gently try to rouse the person. If they are conscious but confused or unable to swallow, do not attempt to give them anything by mouth.
  2. Administer Glucagon (If Available):
    • Glucagon is a hormone that stimulates the liver to release stored glucose into the bloodstream. It is available as an injection or a nasal spray (Baqsimi).
    • Follow the instructions on the glucagon kit carefully.
    • Inject the glucagon into the thigh or arm muscle.
    • If using Baqsimi nasal spray, insert the device into one nostril and press the plunger.
  3. Call for Emergency Medical Assistance (911 or Local Equivalent): Regardless of whether glucagon is available, call emergency services immediately. Severe hypoglycemia can have lasting effects, and professional medical assistance is always necessary. Even if the person appears to respond to glucagon, they still need to be evaluated by medical personnel.
  4. Monitor Breathing and Pulse: Ensure the person is breathing and has a pulse. If not, begin CPR if you are trained to do so.
  5. Once the Person Regains Consciousness:
    • Give them a fast-acting source of glucose, such as fruit juice, glucose tablets, or regular (non-diet) soda.
    • Follow up with a longer-acting carbohydrate source, such as crackers, bread, or a piece of fruit.
  6. Document the Event: Record the time of the hypoglycemic episode, the steps taken, and the person's response. This information is valuable for healthcare providers in managing their diabetes.

Related reading: The Role Of Insulin How It Helps Control Your Blood Glucose

Important Considerations:

  • Educate Family and Friends: Ensure that family members, friends, and coworkers know how to recognize severe hypoglycemia and administer glucagon.
  • Keep Glucagon Accessible: Always have glucagon readily available, both at home and when traveling. Check the expiration date regularly.
  • Medical Identification: Ensure the person with diabetes wears a medical identification bracelet or necklace indicating their condition.

Related reading: The Role Of Insulin In Blood Glucose Control A Simple Explanation

| Action | Rationale | | :------------------------------------ | :----------------------------------------------------------------------------------------------------------- | | Administer Glucagon | Quickly raises blood sugar levels by stimulating the liver to release glucose | | Call Emergency Medical Services (911) | Provides professional medical assistance and transport to a hospital for further evaluation and treatment | | Provide Fast-Acting Glucose | Replenishes blood sugar levels once the person is conscious, preventing a recurrence of hypoglycemia | | Document the Event | Provides valuable information to healthcare providers for future management and prevention of hypoglycemia |

Related reading: Is A Continuous Glucose Monitor Cgm Worth It Pros And Cons

Preventing Future Episodes of Severe Hypoglycemia

While knowing how to respond in an emergency is crucial, the primary goal should be to prevent severe hypoglycemic episodes from occurring in the first place. Proactive management strategies can significantly reduce the risk.

Key Prevention Strategies:

  • Regular Blood Glucose Monitoring: Frequent monitoring provides valuable insights into blood sugar trends and helps identify potential problems early. Continuous Glucose Monitoring (CGM) systems can be particularly helpful.
  • Careful Medication Management: Work closely with a healthcare provider to adjust insulin dosages or other medications as needed. Never change medication dosages without professional guidance.
  • Consistent Meal Schedules: Eat regular meals and snacks, and avoid skipping meals, especially after taking insulin.
  • Carbohydrate Counting: Learn how to accurately estimate the carbohydrate content of foods to match insulin doses appropriately.
  • Adjustments for Exercise: Monitor blood sugar levels before, during, and after physical activity. Adjust insulin doses or carbohydrate intake as necessary.
  • Limit Alcohol Consumption: If consuming alcohol, do so in moderation and always with food. Check blood sugar levels frequently.
  • Diabetes Education: Participate in comprehensive diabetes education programs to learn about blood sugar management, medication administration, and strategies for preventing complications.
  • Communicate with Healthcare Team: Regularly discuss blood sugar control, hypoglycemic episodes, and any concerns with the healthcare team.

Advanced Technology and Prevention:

  • Insulin Pumps with Continuous Glucose Monitoring (CGM): These systems can automatically adjust insulin delivery based on real-time glucose readings, reducing the risk of hypoglycemia.
  • Automated Insulin Delivery (AID) Systems: Also known as artificial pancreas systems, these advanced technologies further automate blood sugar control, minimizing both highs and lows.

| Prevention Strategy | Benefit | | :----------------------------- | :-------------------------------------------------------------------------------------------------------- | | Regular Blood Glucose Monitoring | Provides timely information about blood sugar levels, allowing for adjustments to prevent hypoglycemia | | Careful Medication Management | Ensures that insulin dosages and other medications are appropriate for the individual's needs | | Consistent Meal Schedules | Provides a predictable source of glucose, reducing the risk of blood sugar drops | | Adjustments for Exercise | Prevents hypoglycemia caused by increased glucose utilization during physical activity |

The Importance of Continuous Education and Support

Managing diabetes and preventing severe hypoglycemia requires ongoing education, support, and collaboration with a healthcare team. People with diabetes should be encouraged to actively participate in their care and to seek help whenever needed.

Key Resources and Support Systems:

  • Certified Diabetes Educators (CDEs): Provide comprehensive diabetes education, including blood sugar management, medication administration, and lifestyle modifications.
  • Endocrinologists: Physicians specializing in hormone disorders, including diabetes.
  • Primary Care Physicians: Provide ongoing medical care and coordinate with specialists.
  • Diabetes Support Groups: Offer emotional support, shared experiences, and practical advice from peers.
  • Online Resources: Numerous websites and online communities provide information, resources, and support for people with diabetes. Examples include the American Diabetes Association (ADA) and the Juvenile Diabetes Research Foundation (JDRF).

By prioritizing education, promoting self-management, and fostering strong support systems, it is possible to significantly reduce the incidence of severe hypoglycemia and improve the lives of people with diabetes.