Severe Hypoglycemia: An Emergency Guide on What to Do

02 Sep 2025

Severe Hypoglycemia: An Emergency Guide on What to Do Severe hypoglycemia, or low blood sugar, is a dangerous condition that can occur in individuals ...

Severe Hypoglycemia: An Emergency Guide on What to Do

Severe hypoglycemia, or low blood sugar, is a dangerous condition that can occur in individuals with diabetes, especially those using insulin or certain oral medications. It happens when the blood glucose levels drop to a point where the individual is unable to treat themselves. This can lead to confusion, seizures, loss of consciousness, and, in rare cases, even death. This guide provides detailed, step-by-step instructions on how to recognize, respond to, and prevent severe hypoglycemia, focusing on emergency situations.

Understanding Severe Hypoglycemia

Before diving into emergency response, it’s essential to understand what severe hypoglycemia is and why it's a medical emergency.

What is Hypoglycemia?

Hypoglycemia is defined as low blood sugar, generally below 70 mg/dL (3.9 mmol/L). Symptoms can range from mild to severe, and the presentation can vary from person to person.

Why Does Severe Hypoglycemia Occur?

Several factors can cause severe hypoglycemia in people with diabetes, including:

  • Excessive Insulin: Taking too much insulin or other diabetes medications.
  • Missed or Delayed Meals: Skipping meals or delaying eating can cause blood sugar to drop.
  • Increased Physical Activity: Unplanned or excessive exercise without adjusting medication or food intake.
  • Alcohol Consumption: Alcohol can interfere with the liver's ability to release glucose into the bloodstream.
  • Kidney or Liver Problems: Impaired kidney or liver function can affect medication metabolism and glucose regulation.

Related reading: Decoding Your Diabetes The Role Of Glucose Insulin And Blood Sugar

| Factor | Explanation | | --------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Excessive Insulin | Too much insulin drives glucose out of the blood and into cells at an accelerated rate, resulting in low blood sugar. | | Missed Meals | Without regular intake of carbohydrates, the body’s glucose supply depletes, especially when taking glucose-lowering medications. | | Increased Exercise | Exercise increases glucose uptake by muscles. If not compensated with additional carbohydrates, it can lead to hypoglycemia. | | Alcohol | Alcohol impairs the liver’s gluconeogenesis (glucose production) process, which is critical during fasting or when blood sugar levels are dropping. | | Kidney/Liver Problems | These organs are essential for regulating glucose metabolism and clearing medications. Dysfunction can lead to erratic blood sugar levels. |

Recognizing the Signs and Symptoms of Severe Hypoglycemia

Being able to identify the signs and symptoms of severe hypoglycemia is the first critical step in providing appropriate assistance.

Mild to Moderate Symptoms

Before severe hypoglycemia sets in, an individual may experience:

  • Shakiness
  • Sweating
  • Dizziness or Lightheadedness
  • Hunger
  • Irritability or Anxiety
  • Confusion
  • Rapid Heartbeat
  • Pale Skin

Severe Symptoms

Severe hypoglycemia symptoms indicate the person needs immediate assistance:

  • Inability to Eat or Drink
  • Unconsciousness or Passing Out
  • Seizures or Convulsions
  • Combativeness or Erratic Behavior
  • Difficulty Speaking

It's essential to note that some people may not experience the early warning signs, making regular blood glucose monitoring crucial.

Immediate Actions to Take During a Severe Hypoglycemic Episode

When someone is experiencing severe hypoglycemia, prompt action is crucial. Here’s a step-by-step guide:

Step 1: Assess the Situation

First, ensure the person is safe from immediate danger. If they are conscious but confused, try to determine if they have diabetes. Look for a medical ID bracelet or necklace indicating diabetes. Ask them or someone nearby if they have diabetes and if they have taken insulin.

Step 2: Do Not Administer Oral Food or Liquids if Unconscious

If the person is unconscious, do NOT attempt to give them food or drink by mouth, as they could choke. Lay the person on their side (recovery position) to prevent aspiration if vomiting occurs.

Step 3: Administer Glucagon

Glucagon is a hormone that raises blood sugar levels by stimulating the liver to release stored glucose. It is the primary treatment for severe hypoglycemia in individuals who are unable to take oral carbohydrates.

  • Locate the Glucagon Kit: Ensure you know where the glucagon kit is located if the person is known to have diabetes. It should be part of their emergency plan.
  • Check Expiration Date: Verify the glucagon is not expired. Expired glucagon may not be effective.
  • Prepare the Injection: Follow the instructions in the glucagon kit, which generally involves mixing the powdered glucagon with the provided liquid.
  • Administer the Injection: Inject the glucagon into the thigh, upper arm, or buttocks. You can inject through clothing if necessary.

Here’s a simple breakdown of glucagon administration:

| Step | Action | Notes | | ----- | ------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------- | | 1 | Locate the Glucagon Kit | Keep the kit in an easily accessible location. | | 2 | Check Expiration Date | Do not use expired glucagon. | | 3 | Mix the Glucagon | Follow the specific instructions included in the kit. | | 4 | Administer the Injection | Inject into a muscle (thigh, upper arm, or buttocks). The person does not need to be undressed. |

Step 4: Call for Emergency Medical Services (EMS)

Even after administering glucagon, call emergency services (911 in the US). The individual requires further medical evaluation to determine the cause of the hypoglycemia and prevent recurrence.

  • Provide Details: When calling, provide the operator with as much information as possible, including the person’s condition, that glucagon has been administered, and their location.
  • Follow Instructions: Follow any instructions provided by the emergency services operator.

Step 5: Monitor the Person

After administering glucagon, monitor the person closely. Note the time the glucagon was given. Most individuals will regain consciousness within 5-15 minutes.

  • If Consciousness is Regained: Once conscious and able to swallow, give the person a fast-acting source of glucose, such as juice, regular soda, or glucose tablets. Follow this with a longer-acting source of carbohydrates, like crackers and peanut butter or a sandwich, to stabilize blood sugar levels.
  • If No Improvement: If there is no improvement within 15 minutes, and EMS has not yet arrived, another dose of glucagon may be given if available and if you are trained to do so.

Post-Emergency Care and Prevention

After an episode of severe hypoglycemia, comprehensive care and preventive strategies are essential.

Medical Evaluation

The individual should be evaluated by a healthcare provider to identify the cause of the severe hypoglycemia and adjust their diabetes management plan accordingly.

  • Review Medications: A review of medications, particularly insulin and oral diabetes drugs, is necessary to ensure appropriate dosages and timing.
  • Assess Dietary Habits: Evaluate meal timing, carbohydrate intake, and any changes in appetite.
  • Assess Physical Activity: Discuss exercise habits and strategies for adjusting medication or food intake to prevent hypoglycemia during and after activity.

Adjusting the Diabetes Management Plan

Related reading: The Role Of Insulin In Achieving Control Of Blood Glucose Levels

Based on the evaluation, the healthcare provider may recommend changes to the individual’s diabetes management plan.

  • Medication Adjustments: Insulin dosages or timing may need to be adjusted.
  • Dietary Modifications: Adjusting meal timing, carbohydrate content, or snacking habits may be necessary.
  • Blood Glucose Monitoring: Increasing the frequency of blood glucose monitoring, particularly before meals, before bedtime, and after exercise, can help identify patterns and prevent future episodes.

Hypoglycemia Awareness Training

Enhancing hypoglycemia awareness is crucial for both the individual and their caregivers.

  • Recognizing Symptoms: Educate the individual and their family members about the early signs and symptoms of hypoglycemia and the importance of prompt treatment.
  • Using a Continuous Glucose Monitor (CGM): CGMs can provide real-time glucose readings and alert the individual to impending hypoglycemia, allowing for proactive intervention.
  • Emergency Preparedness: Develop a written emergency plan that includes instructions on how to administer glucagon and when to call for emergency medical services.

Practical Strategies for Preventing Hypoglycemia

Preventing hypoglycemia involves proactive management and lifestyle adjustments.

Consistent Meal Timing and Composition

  • Regular Meals: Avoid skipping or delaying meals. Aim for consistent meal times each day.
  • Balanced Nutrition: Ensure meals contain a balance of carbohydrates, proteins, and fats to promote stable blood glucose levels.
  • Carbohydrate Counting: Work with a registered dietitian or diabetes educator to learn how to count carbohydrates and match insulin doses to carbohydrate intake.

Exercise Management

  • Monitor Glucose Levels: Check blood glucose levels before, during, and after exercise to identify how activity affects your glucose levels.
  • Adjust Insulin or Carbohydrates: Adjust insulin doses or carbohydrate intake as needed to prevent hypoglycemia during and after exercise.
  • Carry Snacks: Keep a fast-acting source of glucose, such as glucose tablets or juice, on hand during exercise in case of hypoglycemia.

Safe Alcohol Consumption

  • Eat While Drinking: Always consume alcohol with food to slow the absorption of alcohol and help maintain stable blood glucose levels.
  • Monitor Blood Glucose: Check blood glucose levels frequently while drinking alcohol, as alcohol can interfere with the liver’s ability to release glucose.
  • Know Your Limits: Limit alcohol intake to moderate amounts (one drink per day for women, two drinks per day for men) to minimize the risk of hypoglycemia.

Regular Blood Glucose Monitoring

  • Frequent Checks: Monitor blood glucose levels as directed by your healthcare provider, especially before meals, before bedtime, and after exercise.
  • Use a CGM: Consider using a continuous glucose monitor (CGM) for real-time glucose readings and alerts.
  • Keep a Log: Record blood glucose levels and any associated symptoms or factors that may have contributed to hypoglycemia.

Educate Family and Friends

  • Teach Recognition: Educate family members, friends, and coworkers about the signs and symptoms of hypoglycemia and how to respond in an emergency.
  • Glucagon Training: Ensure that at least one person close to you knows how to administer glucagon.
  • Emergency Contact: Keep a list of emergency contacts readily available.

The Role of Technology in Preventing Hypoglycemia

Advancements in technology have greatly improved the management of diabetes and the prevention of hypoglycemia.

Continuous Glucose Monitors (CGMs)

CGMs provide real-time glucose readings and can alert the user to impending hypoglycemia or hyperglycemia. They can significantly improve glucose control and reduce the risk of severe hypoglycemia.

  • Real-Time Readings: CGMs provide continuous glucose readings, allowing for proactive management.
  • Alerts and Alarms: CGMs can be set to alert the user when glucose levels are dropping too low or rising too high.
  • Trend Data: CGMs provide trend data, allowing the user and their healthcare provider to identify patterns and adjust their management plan accordingly.

Insulin Pumps

Insulin pumps deliver a continuous, basal dose of insulin throughout the day, as well as bolus doses for meals. They can be programmed to adjust insulin delivery based on glucose levels, reducing the risk of hypoglycemia.

Related reading: Building Your Perfect Diabetic Diet For Stable Blood Sugar Levels

  • Basal Insulin: Insulin pumps deliver a steady, basal rate of insulin, which can be adjusted to meet individual needs.
  • Bolus Insulin: Insulin pumps allow for precise bolus doses of insulin for meals, reducing the risk of post-meal hyperglycemia.
  • Suspend Feature: Some insulin pumps have a suspend feature that automatically stops insulin delivery if glucose levels drop too low, preventing hypoglycemia.

Artificial Pancreas Systems

Artificial pancreas systems combine a CGM, an insulin pump, and an algorithm to automatically adjust insulin delivery based on glucose levels. These systems can significantly improve glucose control and reduce the risk of hypoglycemia.

  • Automated Insulin Delivery: Artificial pancreas systems automatically adjust insulin delivery based on glucose levels, minimizing the risk of hypoglycemia and hyperglycemia.
  • Closed-Loop Systems: These systems create a closed loop between the CGM and the insulin pump, allowing for automated glucose management.
  • Improved Glucose Control: Artificial pancreas systems have been shown to improve glucose control and reduce the risk of complications in people with diabetes.

By understanding severe hypoglycemia, recognizing its symptoms, taking prompt action, and implementing preventive strategies, individuals with diabetes and their caregivers can significantly reduce the risk of this life-threatening condition. Regular medical evaluations, adjustments to the diabetes management plan, and education about hypoglycemia awareness are essential for maintaining stable blood glucose levels and preventing severe episodes. Embrace technology, such as CGMs and insulin pumps, to further enhance glucose control and improve overall quality of life.