High Blood Sugar Without Diabetes: Cushing's Syndrome, Steroids, and More

23 Aug 2025

High Blood Sugar Without Diabetes: Cushing's Syndrome, Steroids, and More Related reading: How To Check Your Blood Sugar Level Correctly At HomeRelate...

High Blood Sugar Without Diabetes: Cushing's Syndrome, Steroids, and More

Related reading: How To Check Your Blood Sugar Level Correctly At Home

Related reading: The 7 Biggest Dangers Of Uncontrolled High Blood Sugar

High blood sugar, or hyperglycemia, is typically associated with diabetes, but there are several other conditions and factors that can cause elevated blood sugar levels in non-diabetic individuals. Here, we'll explore some of these scenarios, including Cushing's syndrome, steroid use, and more.

Cushing's Syndrome

Cushing's syndrome is a rare endocrine disorder that occurs when the body is exposed to high levels of cortisol, a hormone produced by the adrenal gland. This excess cortisol can cause a range of symptoms, including high blood sugar, weight gain, and fatigue. Cushing's syndrome is usually caused by a tumor on the pituitary gland or adrenal gland, and treatment typically involves surgery to remove the tumor.

Steroid Use

Steroids, or corticosteroids, are medications that are often used to treat a range of conditions, including inflammatory disorders and asthma. However, long-term steroid use can cause high blood sugar, particularly in people who are prone to diabetes. This is because steroids can increase insulin resistance, making it harder for the body to regulate blood sugar levels.

Polycystic Ovary Syndrome (PCOS)

PCOS is a hormonal disorder that affects women of childbearing age. It is characterized by irregular menstrual periods, high levels of androgen hormones, and high blood sugar. Women with PCOS are at increased risk of developing insulin resistance and type 2 diabetes.

Acromegaly

Acromegaly is a rare disorder caused by excess growth hormone, which can lead to high blood sugar levels. This condition is usually caused by a benign tumor on the pituitary gland, and treatment typically involves surgery to remove the tumor.

Insulin Resistance

Insulin resistance is a condition in which the body's cells become less responsive to insulin, making it harder for glucose to enter the cells. This can lead to high blood sugar levels, even in people who do not have diabetes. Insulin resistance can be caused by a range of factors, including obesity, physical inactivity, and a diet high in sugar and refined carbohydrates.

Related reading: A Day In The Life A Guide To Managing Type 1 Diabetes

Adrenal Insufficiency

Adrenal insufficiency, also known as Addison's disease, is a condition in which the adrenal glands do not produce enough cortisol and aldosterone hormones. This can lead to high blood sugar levels, as well as fatigue, weight loss, and skin changes.

Other Causes

There are several other conditions and factors that can cause high blood sugar without diabetes, including:

  • Prolonged stress and cortisol elevation
  • Certain medications, such as certain psychiatric medications and beta blockers
  • Sleep disorders, such as sleep apnea
  • Hormonal imbalances, such as thyroid disorders
  • Certain infections, such as tuberculosis

Managing High Blood Sugar

If you have high blood sugar without diabetes, it is essential to work with your healthcare provider to manage your condition. This may involve making lifestyle changes, such as improving your diet and increasing physical activity. In some cases, medication may be necessary to help regulate blood sugar levels.

Conclusion

High blood sugar without diabetes is a complex condition that can be caused by a range of factors, including Cushing's syndrome, steroid use, PCOS, and insulin resistance. By understanding the causes of high blood sugar and working with your healthcare provider, you can take steps to manage your condition and reduce your risk of developing long-term complications.