Medicines That Worsen Insulin Resistance (Do You Take One?) [8b66c9]

2025-07-18

Post Time: 2025-07-18

Prediabetes is a condition where blood sugar levels are higher than normal but not yet high enough to be classified as type 2 diabetes. It's a critical stage, often a warning sign, that indicates an increased risk of developing diabetes, heart disease, and stroke. Understanding the prediabetes range, its implications, and how to address it proactively is crucial for safeguarding your long-term health. This article delves into what you need to know about prediabetes, from diagnosis to lifestyle changes.

Understanding the Prediabetes Range: Key Metrics

Identifying prediabetes relies on specific blood sugar measurements, typically obtained through one of these tests:

Test Normal Range Prediabetes Range Diabetes Range
Fasting Plasma Glucose (FPG) Less than 100 mg/dL 100 to 125 mg/dL 126 mg/dL or higher
Oral Glucose Tolerance Test (OGTT) Less than 140 mg/dL after 2 hours 140 to 199 mg/dL after 2 hours 200 mg/dL or higher after 2 hours
Hemoglobin A1c (HbA1c) Less than 5.7% 5.7% to 6.4% 6.5% or higher
  • Fasting Plasma Glucose (FPG): Measures your blood sugar level after an overnight fast (usually 8 hours).
  • Oral Glucose Tolerance Test (OGTT): Measures how your body processes sugar after consuming a specific sugary drink. The blood sugar level is checked 2 hours after the drink.
  • Hemoglobin A1c (HbA1c): Reflects your average blood sugar level over the past 2-3 months. It provides a longer-term view compared to the daily variations seen in FPG and OGTT.

It's worth noting that individuals may have prediabetes diagnosed through one test but not another, which is why healthcare providers might recommend multiple tests for a conclusive diagnosis. The specific test to be done is something that should be decided between a person and their healthcare provider.

The Significance of Early Detection and Intervention

Early detection of prediabetes is vital. This stage is often asymptomatic, meaning most people do not experience noticeable symptoms, which makes it easy to overlook the condition without testing. However, underlying damage to your health may already be in progress. By recognizing and acting on a prediabetes diagnosis, you can significantly reduce your chances of progressing to type 2 diabetes, along with mitigating other health risks like heart disease, nerve damage (neuropathy), kidney issues (nephropathy) and eye problems (retinopathy) which have connections to glucose imbalances.

This proactive step involves lifestyle modifications, which are generally more effective at the prediabetes stage. Studies have shown that early lifestyle changes can delay or even reverse prediabetes, ultimately improving long-term health. For instance, the Diabetes Prevention Program (DPP), a major US study, demonstrated that a lifestyle intervention including a 5-7% weight loss and 150 minutes per week of moderate intensity exercise resulted in a 58% reduced risk of progressing to diabetes.

Practical Steps to Manage and Reverse Prediabetes

Once you've been diagnosed with prediabetes, the focus shifts to lifestyle modifications. Here are actionable strategies to bring your blood sugar levels into a healthier range:

  1. Dietary Changes:

    • Focus on Whole Foods: Prioritize foods such as vegetables, fruits, whole grains, lean proteins, and healthy fats. Minimize processed foods, sugary drinks, and high saturated and trans fats.
    • Control Portion Sizes: Practice mindful eating and be aware of how much food you are consuming at each meal. Use smaller plates and bowls to help manage portions.
    • Increase Fiber Intake: Incorporate soluble and insoluble fiber into your diet. Sources include vegetables, fruit, beans, and whole grains. Fiber aids in satiety and helps regulate blood sugar levels.
    • Reduce Sugary Beverages: Eliminate sugary drinks such as soda, sweetened teas, and fruit juices, opting for water, unsweetened teas, and zero calorie drinks.
    • Follow the Plate Method: Fill half your plate with non-starchy vegetables, a quarter with lean protein, and a quarter with carbohydrates.
  2. Regular Physical Activity:

    • Aim for 150 Minutes Weekly: Engage in moderate-intensity aerobic activities like brisk walking, cycling, swimming, or dancing for at least 150 minutes per week. This can be spread throughout the week into smaller, 30-minute sessions.
    • Incorporate Strength Training: Include muscle-strengthening exercises twice a week, like weightlifting or using resistance bands to help build muscle and improve metabolism.
    • Be Active Daily: In addition to dedicated workouts, include physical activity throughout your day like using the stairs, and going for walk during your breaks.
  3. Weight Management:

    • Gradual Weight Loss: If you are overweight or obese, even losing a small amount of weight (5-7%) can significantly improve blood sugar levels. Gradual weight loss is more sustainable and healthier than rapid weight loss.
    • Combine Diet and Exercise: Weight management is most effective when diet and exercise are combined and followed consistently.
    • Consult Professionals: Consult a healthcare provider, dietitian, or nutritionist for personalized advice, tools, and programs that align with your needs and goals.
  4. Stress Management:

    • Identify Stressors: Be aware of your sources of stress and work on effective strategies to mitigate and cope with stressors.
    • Stress Reducing Techniques: Incorporate techniques such as deep breathing, yoga, mindfulness, and spending time in nature to help alleviate daily stress.
    • Prioritize Adequate Rest: Proper rest and sleep also play a key role in blood sugar regulation, so aim for a consistent sleep schedule that allows for 7-9 hours of quality sleep.
  5. Regular Check-Ups:

    • Routine Blood Sugar Monitoring: Follow-up with your healthcare provider and complete regular check-ups and tests as recommended to see your progress.
    • Medication Options: Depending on your situation, in certain cases medications may be recommended if lifestyle modifications alone are not sufficient.

Medication for Prediabetes: When and Why

While lifestyle modifications are the cornerstone of prediabetes management, medications are sometimes considered in specific situations. These medications, such as metformin, may be prescribed for certain high risk individuals such as those who are obese and/or over 60. The use of medications for prediabetes is evaluated on a case-by-case basis and should be discussed and monitored with a healthcare professional. Metformin, is often the first choice, because of its effectiveness and long term safety track record, which works by decreasing glucose production in the liver and increasing insulin sensitivity in muscle tissues.

Medication How it Works Potential Benefits Important Considerations
Metformin Reduces glucose production, increases insulin sensitivity Lowers blood glucose, may reduce heart risks Common side effects include GI issues. Needs to be prescribed by a doctor.
GLP-1 RAs Enhance insulin response and suppress glucagon secretion. Significant A1C reduction & weight loss May have side effects, only available via prescription
SGLT2is Increased glucose excretion through urination. Modest A1C reduction and some weight loss May have side effects, only available via prescription

The decision to start medication, should be made collaboratively with your healthcare team to ensure it aligns with your health needs and goals, with regular monitoring by the prescriber to monitor your individual response and adjust medications as needed.

Key Takeaways

Managing prediabetes is a proactive process that emphasizes lifestyle changes as the foundation, with medications as options under medical supervision when necessary. Early detection, education, and lifestyle modifications are vital in managing and reversing the course of prediabetes to help protect your health and minimize health complications associated with imbalanced blood sugar levels. If you think you are at risk for prediabetes please speak to your healthcare provider to discuss your individual health picture and get specific recommendations.

By making conscious dietary and lifestyle choices you can significantly improve your long-term health.

Which medications worsen Insulin Resistance? There is a long list! Make sure you're not taking one of these medicines that worsen insulin resistance. If you are, talk with your doctor about changing/decreasing/stopping them. The Truth about Insulin Resistance: Daily Minerals: (discount) Become a Tribe-member & get answers: -----Medications that worsen Insulin Resistance----- Thiazides - HCT, HCTZ, indapamide Beta blockers - metoprolol, propranolol, Atenolol Antipsychotics 2nd gen - Abilify, Geodon, Seroquel, Zyprexa fluoroquinolones - Levaquin, Cipro corticosteroids - prednisone, methylprednisolone, prednisolone Niacin - Rx and supplements Diabetes medications Amylin mimetics pramlintide (SymlinPen). Incretin mimetics exenatide immediate-release (Byetta) exenatide extended-release (Bydureon) liraglutide (Victoza) Dipeptidyl-peptidase 4 inhibitors saxagliptin (Onglyza) sitagliptin (Januvia) linagliptin (Tradjenta) GLP-1 Agonists Byetta Ozempic Rybelsus Trulicity Victoza Bydureon Tanzeum Sulfonylureas glyburide (Micronase) glipizide (Glucotrol) glimepiride (Amaryl) chlorpropamide (generic only in the United States) tolazamide (generic only in United States) tolbutamide (generic only in United States) Glinides nateglinide (Starlix) repaglinide (Prandin) ALL Injectable/Inhaled Insulins Humulin, Novolin, Humulin, Novolog, Fiasp, Apidra, Myxredlin, Lantus, Toujeo, Basaglar, Semglee, Levemir, Tresiba, Soiqua, Xutophy, Afrezza, Humalog, at what level blood sugar is dangerous Admelog, Lyumjev LIES MY DOCTOR TOLD ME: Eat REAL SALT: (discount) Our Amazon Store: Our Amazon Favorites: ----- Join me and let's optimize your health! ----- My Website: drberry.com PHD Tshirts/Tanks/Hoodies: Ken D Berry, MD, is a Family Physician and has been practicing Family Medicine in Tennessee for over 20 years, having seen over 25,000 patients in his career so far. Consult your doctor. Don't use this video as medical advice. For Collaborations please email me: [email protected] Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for the advice provided by your doctor or other qualified healthcare professional. Always seek the advice of your physician or other qualified health care professional with questions you may have regarding your medical condition. Although all measures are taken to ensure that the contents of the YouTube channel are accurate and up-to-date, all information contained on it is provided ‘as is’. To the extent permitted by mandatory law, Dr. Ken D. Berry shall not be liable cholesterol and blood sugar lowering foods for any direct, incidental, consequential, indirect, or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content. As watch that tracks blood sugar an Amazon Associate, I earn from qualifying purchases.
Medicines that Worsen Insulin Resistance (Do you take One?)
Medicines That Worsen Insulin Resistance (Do You Take One?) [8b66c9]