Exciting Developments In The Treatment Of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt [3d991b]

2025-07-18

Post Time: 2025-07-18

Continuous Glucose Monitoring (CGM) is rapidly becoming a pivotal technology in the management of diabetes, particularly for older adults. Unlike traditional blood glucose monitoring (BGM), which relies on finger-prick tests at specific points in the day, CGM systems provide real-time glucose readings throughout the day and night. This constant stream of data allows for a much more nuanced and responsive approach to diabetes management, which is especially important given the unique challenges faced by older adults.

Older adults are often more susceptible to fluctuations in blood sugar levels due to factors like medication interactions, changes in dietary habits, decreased kidney function, and cognitive impairments. These fluctuations can increase the risk of both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar). Hypoglycemia, in particular, can be especially dangerous for seniors, increasing their risk of falls, confusion, and even hospitalization. CGM's real-time monitoring provides an early warning system for these events, facilitating quicker interventions. The wealth of data provided by CGM also allows healthcare providers to gain deeper insights into patterns and tailor personalized treatment plans, improving both short and long-term blood sugar control. Moreover, CGM promotes greater patient involvement in diabetes self-management, encouraging better adherence to recommended therapies.

Feature Blood Glucose Monitoring (BGM) Continuous Glucose Monitoring (CGM)
Monitoring Frequency Limited to finger-prick tests at specific times Continuous, real-time readings
Data Availability Isolated readings Comprehensive glucose trends throughout the day
Hypoglycemia Detection Can miss nocturnal or asymptomatic hypoglycemia Early warning, alerts potential events
Trend Analysis Difficult to assess glucose patterns Provides a detailed view of glucose trends over time

How CGM Technology Works: A Detailed Look

Understanding how a CGM system works helps appreciate its capabilities and how it can be integrated into daily life. The main components include:

  1. Sensor: A small, thin filament is inserted just under the skin, usually in the abdomen or upper arm. This sensor measures glucose levels in the interstitial fluid, which surrounds the cells in tissues, and these levels are typically reflective of the levels in blood. The sensor itself does not directly measure blood glucose, but interstitial fluid glucose correlates with it.
  2. Transmitter: A small device attached to the sensor sends data wirelessly (typically via Bluetooth) to a receiver. It is usually rechargeable and typically lasts 3-6 months before replacement.
  3. Receiver/Smart Device: The receiver displays the current glucose level, trends, and sometimes other information, such as graphs of historical data. Nowadays, most modern CGM systems will use your smartphone as a receiver through a dedicated app. Many systems also allow caregivers or healthcare providers to monitor data remotely.

Data Transmission: The sensor continuously measures glucose levels and transmits this data to the receiver every few minutes. This results in near-continuous information about glucose levels and the direction and speed of their change. This feature makes CGM very different from conventional BGMs which only provide snapshots at specific times.

Calibration: Some older CGM systems require calibration using finger-stick blood glucose measurements once or twice a day to ensure accuracy. However, many newer systems are factory-calibrated, minimizing or eliminating the need for this process. These factory-calibrated devices use advanced algorithms for better accuracy.

Alarm Features: CGM devices often have customizable alarms that warn the user when their glucose level is too high, too low, or rapidly changing. These alarms are adjustable, based on an individual's personal target ranges which are determined in consultation with the diabetes care team.

The sensor generally needs to be replaced every 7-14 days, depending on the brand. The transmitter, on the other hand, usually needs replacement every 3-6 months.

This continuous data collection allows for proactive management and significantly reduces the lag time between a change in glucose levels and necessary treatment or lifestyle adjustments. This functionality is extremely important in preventing drastic blood sugar swings, especially in older adults, who may be less sensitive to the warning signs of highs and lows.


Practical Benefits of CGM for Older Adults: More Than Just Numbers

While it's clear that CGM provides detailed data, its real impact lies in how this data can be used to improve daily life for older adults. Here are some of the key practical benefits:

  1. Improved Hypoglycemia Awareness: Traditional finger-prick testing can often miss overnight episodes of low blood sugar or those which have mild or unspecific symptoms. CGM allows seniors and their caretakers to know when glucose levels start to fall to a dangerous point and take appropriate measures, often even before they begin to experience any overt symptoms of hypoglycemia. This is critical in avoiding confusion, falls, and other serious events associated with low blood sugar.
  2. Personalized Diabetes Management: By providing real-time glucose data, CGM helps identify trends related to meals, exercise, and medication. This enables individuals and their healthcare team to fine-tune treatment plans more accurately than just relying on HbA1c measures, and adjust medication dosages, timing, or dietary plans with data to back those adjustments. The granular data is more immediately relevant and allows quicker responses, preventing glucose spikes and dips. For example, someone might discover their blood sugar always spikes after lunch, which can prompt modifications to the type of food or amount they eat at that meal.
  3. Reduced Need for Finger-Stick Testing: While many older CGMs still require some finger-stick testing for calibration purposes, the need for frequent testing is greatly reduced, improving patient comfort and compliance. Newer generations of devices are factory-calibrated and require little to no finger-sticks.
  4. Enhanced Patient Empowerment: Access to detailed glucose data allows individuals to take more active control over their diabetes management. They become partners in their care, rather than simply passive recipients of instructions. This empowerment can lead to better adherence to prescribed therapies and more informed self-care decisions.
  5. Remote Monitoring: Many CGM systems allow data to be shared with caregivers or healthcare providers in real time. This feature can be particularly beneficial for older adults living alone or who are being supported by family or home health staff. It enables a collaborative approach to diabetes management and allows for prompt intervention in case of emergencies.
  6. Reducing Fear of the Unknown: In many patients, the constant uncertainty around blood sugar can be anxiety provoking. With CGM, real time information and clear, understandable trends, can bring clarity, and often ease concerns and empower more engagement.
Benefit How CGM Contributes Practical Application
Hypoglycemia Awareness Real-time monitoring, alarms for low glucose Prompt response to prevent falls or cognitive decline
Personalized Treatment Identifies trends related to meals and exercise Tailored diet plans and medication adjustments
Reduced Finger Sticks Minimizes need for frequent testing Increased patient comfort and compliance
Patient Empowerment Increased access to personal health data Greater involvement in diabetes self-management

Potential Challenges and How to Overcome Them

While the benefits of CGM are significant, some challenges need to be addressed for older adults to adopt and use these systems effectively. Here are some potential difficulties and strategies to overcome them:

  1. Technological Complexity: Some older adults may struggle with the technology, including sensor insertion, device pairing, and navigating smartphone apps. This can be addressed by thorough training, demonstrations, and clear user manuals. A healthcare team and caregivers can also offer additional support. Simple and intuitive device design is a crucial factor as well.
  2. Cost: CGM systems are often more expensive than traditional blood glucose meters and test strips, which may be a concern for older adults living on a fixed income. Insurance coverage will vary. Exploring available insurance plans and government programs can significantly lower the financial barrier. Patient assistance programs from manufacturers are often also a viable source of savings and discounts.
  3. Sensor Insertion: The insertion process itself, despite being generally painless, can create some anxiety. Some adults can find sensor insertion challenging, especially if they have limited dexterity. Options such as pre-loaded applicators, or caregivers assistance can improve this process. Clear instruction and support are key.
  4. Data Interpretation: The detailed data provided by CGM can sometimes be overwhelming and require a certain degree of digital literacy. Education about data interpretation by the care team is essential, particularly regarding how to utilize the information to make necessary lifestyle and medication changes. Caregivers, friends, and family can also assist with this task, especially if they have a greater degree of digital comfort.
  5. Skin Sensitivity/Adhesives: Allergic or contact dermatitis is an occasional concern with adhesive-backed sensors. Precautionary application of protective barrier film can significantly reduce skin irritation from adhesive and sensors. If severe skin issues arise, there are hypoallergenic alternatives that could be tested. Rotating sensor insertion locations, and ensuring that the skin is kept clean before sensor application can greatly improve tolerance.
Challenge Strategies to Overcome
Technological Complexity Comprehensive training, simple device design
Cost Explore insurance coverage and patient assistance programs
Sensor Insertion Use pre-loaded applicators, caregiver support, good practice
Data Interpretation Healthcare professional education, family support
Skin Sensitivity Barrier film application, hypoallergenic adhesives, location rotation

Title 5: Conclusion: A Transformative Tool for Healthy Aging

Continuous Glucose Monitoring represents a major step forward in the management of diabetes, particularly for older adults. Its ability to provide continuous, real-time glucose data empowers individuals, caregivers, and healthcare providers to take a proactive and personalized approach to blood sugar management. While some challenges do exist in terms of technological literacy, cost, and data interpretation, with proper training, support and practical strategies, the practical benefits – including enhanced hypoglycemia awareness, personalized therapy adjustments, and patient empowerment – far outweigh the obstacles.

The future of diabetes care in older adults is definitely heading toward increased integration of technology. As CGM devices become more user-friendly, affordable, and widely accepted, their potential to improve blood sugar control, reduce the risks associated with hypo and hyperglycemia, and ultimately improve the quality of life for older adults will undoubtedly increase. Integrating CGM into healthcare practice promises a more tailored and efficient diabetes management model for all and particularly, for older adults and will serve as a key component of geriatric care, allowing people to manage their diabetes more effectively as they continue to age.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves. Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused foods bad for high blood sugar by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost. There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine. In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy. === 0:00 Intro 5:35 The Scope of the Problem 8:09 Diabetic Neuropathy 11:49 Neuropathy Following Chemotherapy 14:21 Viral Infections: HIV Treatment & Covid 16:56 Why Mitochondria are Essential in This 19:44 Pharmaceutical Study of Neuropathy 24:57 Aldose reductase inhibitor 29:31 Why This Approach is Different 37:44 How Antimuscarinics Work 48:10 Metrics for Getting FDA Approval 58:42 Funding the Research 1:01:53 Conclusion ==== Nigel A. Calcutt, Ph.D. ook both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Following what is the treatment for low blood sugar post-doctoral research in the Department of Pharmacology at St. Bartholomew’s Hospital, London and blood sugar 137 in the Department of Anesthesiology at the University of California San Diego, he was appointed to the faculty of the Department of Pathology at UC San Diego in 1993. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful but nevertheless entertaining and informative attempt to generate diabetic chickens in the laboratory of the esteemed ornithologist Professor David Tomlinson. Undeterred by the pitiful paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his academic career, with a particular interest in translational studies. Dr. Calcutt is also a co-founder of the biotechnology company WinSanTor Inc. and the non-profit organization Diabetes Research Connection. Paul Fernyhough PhD received his PhD in biochemistry from the department of Biochemistry at University of Sheffield. He then carried out postdoctoral research at Colorado State University, Kings College London and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College. He subsequently worked as a tenured lecturer in the School of Biological Sciences at the University of Manchester. Dr. Fernyhough moved to Winnipeg in 2004 and set up a neuroscience research group at St Boniface Hospital Albrechtsen Research Centre and holds a tenured professorship in the Department of Pharmacology & Therapeutics at University of Manitoba. Dr. Fernyhough’s research interest is in the cell biology underlying neurodegenerative disorders of the peripheral nervous system with a focus on the impact of diabetes. A biotech start-up, WinSanTor Inc, has been established and is directing phase 2 clinical trials in diabetic neuropathy and chemotherapy-induced peripheral neuropathy. ___________________________ Instagram: Website: Subscribe to our channel:
Exciting Developments in the Treatment of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt
Exciting Developments In The Treatment Of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt [3d991b]